Clevudine - CISMeF

Preferred Label : Clevudine;

NCIt synonyms : 2'-Fluoro-5-methyl-beta-L-arabinofuranosyluracil; L-FMAU; 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)thymine;

NCIt definition : A synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.;

UNII : IN51MVP5F1;

InChIKey : GBBJCSTXCAQSSJ-XQXXSGGOSA-N;

CAS number : 163252-36-6;

Drug name : Levovir; Revovir;

Chemical formula : C10H13FN2O5;

Details

Origin ID

C95210;

UMLS CUI

C0045212;

Automatic exact mappings (from CISMeF team)
- Clevudine [ICD-11 Extension code]
Currated CISMeF NLP mapping
- clevudine [MeSH Supplementary Concept]
- clevudine [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- clevudine [ATC Code]
- clevudine [MeSH concept]
- clevudine [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- clevudine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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