Preferred Label : Triazene Derivative TriN2755;
NCIt definition : A synthetic triazene derivative with antineoplastic activity. Upon metabolic activation
via N-demethylation, TriN2755 is converted into highly reactive carbocations that
can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting
DNA replication and repair, and subsequently inducing apoptosis. This agent has high
hydrophilicity and photostability and shows a favorable toxicity profile over the
other triazenes.;
Molecule name : TriN2755;
NCI Metathesaurus CUI : CL426697;
Origin ID : C95208;
UMLS CUI : C2986993;
Semantic type(s)
- concept_is_in_subset
