" /> Depatuxizumab - CISMeF





Preferred Label : Depatuxizumab;

NCIt synonyms : anti-EGFR mAb ABT-806; anti-EGFR MoAb ABT-806; Immunoglobulin G1, Anti-(Human Epidermal Growth Factor Receptor) (Human-mus musculus Monoclonal ABT-806 Heavy Chain), Disulfide with Human-mus musculus Monoclonal ABT-806 Light Chain, Dimer;

NCIt definition : A humanized monoclonal antibody (MoAb) against human epidermal growth factor receptor (EGFR) with antineoplastic activity. Depatuxizumab targets the EGFR deletion variant, de2-7 EGFR as well as wild-type EGFR expressed in cells overexpressing the receptor, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization result in an inhibition in signal transduction and anti-proliferative effects. This MoAb targets cells expressing aberrant EGFR, hence making it an ideal candidate for generation of radioisotope or toxin conjugates.;

UNII : W984C353CG;

CAS number : 1471999-69-5;

Molecule name : ABT-806; mAb-806;

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30/05/2025


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