" /> Depatuxizumab - CISMeF





Preferred Label : Depatuxizumab;

NCIt synonyms : anti-EGFR mAb ABT-806; anti-EGFR MoAb ABT-806; Immunoglobulin G1, Anti-(Human Epidermal Growth Factor Receptor) (Human-mus musculus Monoclonal ABT-806 Heavy Chain), Disulfide with Human-mus musculus Monoclonal ABT-806 Light Chain, Dimer;

NCIt definition : A humanized monoclonal antibody (MoAb) against human epidermal growth factor receptor (EGFR) with antineoplastic activity. Depatuxizumab targets the EGFR deletion variant, de2-7 EGFR as well as wild-type EGFR expressed in cells overexpressing the receptor, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization result in an inhibition in signal transduction and anti-proliferative effects. This MoAb targets cells expressing aberrant EGFR, hence making it an ideal candidate for generation of radioisotope or toxin conjugates.;

UNII : W984C353CG;

CAS number : 1471999-69-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1471999-69-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ABT-806; mAb-806;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
12/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.