Preferred Label : Carbon C-13 Dextromethorphan;
NCIt synonyms : 13C-dextromethorphan; [(13)C]-DM;
NCIt definition : A radioconjugate consisting of dextromethorphan, a synthetic, methylated dextrorotatory
analogue of levorphanol, conjugated with carbon-13 [(13)C] with radiotracer activity.
(13)C-dextromethorphan can be used in a breath-test phenotype assay of CYP2D6 activity,
based on the principle that CYP2D6-mediated O-demethylation cleaves a (13)CH3 that
enters the body's carbon pool to be eliminated ultimately as (13)CO2 in expired air,
which can be measured. The (13)C-dextromethorphan breath test may prove useful in
identifying poor CYP2D6 metabolizers of such important clinical drugs as tamoxifen.;
NCI Metathesaurus CUI : CL426690;
Origin ID : C95199;
UMLS CUI : C2986986;
Semantic type(s)
- concept_is_in_subset
