Actinomycin C2

Preferred Label : Actinomycin C2;

NCIt synonyms : Actinomycin D, 2a-D-Alloisoleucine-;

NCIt definition : A natural analogue of actinomycin, a chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin C2 inhibits DNA replication as well as RNA and protein synthesis by various mechanisms including, intercalating into the minor groove of DNA and interfering with the function of topoisomerase II. In addition, actinomycin C2 appears to block the interaction between the SH2 domain of growth factor receptor-bound protein-2 (GRB2) and the Src homology 2 domain containing transforming protein 1 adaptor protein SHC, which plays a key role in the Ras signaling pathway thereby halting cellular differentiation and proliferation.;

UNII : 719U3YSA1F;

InChIKey : QCXJFISCRQIYID-GKYLFGMSSA-N;

CAS number : 2612-14-8;

Chemical formula : C63H88N12O16;

NSC code : 87221;

PubMed : 10888331;

Details

Origin ID

C95198;

UMLS CUI

C0762401;

Currated CISMeF NLP mapping
- actinomycin C2 [MeSH concept]
- actinomycin C2 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- actinomycin C2 [MeSH concept]
- actinomycin C2 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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