" /> Vosaroxin - CISMeF





Preferred Label : Vosaroxin;

NCIt synonyms : Voreloxin; 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid;

NCIt definition : A small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure.;

UNII : K6A90IIZ19;

InChIKey : XZAFZXJXZHRNAQ-STQMWFEESA-N;

CAS number : 175414-77-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 175414-77-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SNS-595; AG-7352; SPC 595; SNS 595;

Chemical formula : C18H19N5O4S;

Codes from synonyms : 546;

PubMed : 20233886;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.