" /> Vosaroxin - CISMeF





Preferred Label : Vosaroxin;

NCIt synonyms : Voreloxin; 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid;

NCIt definition : A small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure.;

UNII : K6A90IIZ19;

InChIKey : XZAFZXJXZHRNAQ-STQMWFEESA-N;

CAS number : 175414-77-4;

Molecule name : SNS-595; AG-7352; SPC 595; SNS 595;

Chemical formula : C18H19N5O4S;

Codes from synonyms : 546;

PubMed : 20233886;

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31/05/2025


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