NCIt definition : A small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin
intercalates into DNA in a site-specific manner and blocks the re-ligation process
carried out by topoisomerase II during DNA replication. As a result, inhibition of
DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at
G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity
profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines,
hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate,
and thereby evades the common mechanism for multidrug resistance; and it has limited
distribution to normal tissues and a more chemically stable molecular structure.;
UNII : K6A90IIZ19;
InChIKey : XZAFZXJXZHRNAQ-STQMWFEESA-N;
CAS number : 175414-77-4;
Molecule name : SNS-595; AG-7352; SPC 595; SNS 595;