Macimorelin - CISMeF

Preferred Label : Macimorelin;

NCIt synonyms : Solorel; D-Tryptophanamide,2-methylalanyl-N-[(1R)-1-(formylamino)-2-(1H-indol-3-yl)ethyl]-;

NCIt definition : An orally available synthetic mimetic of the growth hormone (GH) secretagogue ghrelin with potential anti-cachexia activity. Upon oral administration, macimorelin mimics endogenous ghrelin by stimulating appetite and binds to the growth hormone secretagogue receptor GHSR in the central nervous system, thereby mimicking the GH-releasing effects of ghrelin from the pituitary gland. Stimulation of GH secretion increases insulin-like growth factor-I (IGF-I) levels which may further stimulate protein synthesis. In addition, ghrelin reduces the production of pro-inflammatory cytokines, which may play a direct role in cancer-related loss of appetite.;

UNII : 8680B21W73;

InChIKey : UJVDJAPJQWZRFR-DHIUTWEWSA-N;

CAS number : 381231-18-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 381231-18-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AEZS-130; EP 1572; JMV 1843;

Chemical formula : C26H30N6O3;

Details

Origin ID

C95123;

UMLS CUI

C2986922;

Automatic exact mappings (from CISMeF team)
- Macimorelin [LOINC Challenge]
- Macimorelin [ICD-11 Extension code]
- macimorelin [ATC Code]
Currated CISMeF NLP mapping
- Macimorelin (substance) [SNOMED CT concept]
- macimorelin [MeSH concept]
- macimorelin [MeSH Supplementary Concept]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
UMLS correspondences (same concept)
- Macimorelin [LOINC Challenge]
- Macimorelin (substance) [SNOMED CT concept]
- Product containing macimorelin (medicinal product) [SNOMED CT concept]
- macimorelin [MeSH concept]
- macimorelin [ATC Code]
- macimorelin [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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