" /> Tegafur-Uracil - CISMeF





Preferred Label : Tegafur-Uracil;

NCIt synonyms : Uracil/Tegafur (UFT); Uracil and Tegafur; UFT; Oral Fluorouracil-Uracil; Uracil and Tetrahydrofuranyl-5-Fluorouracil; Uracil and Ftorafur; Tegafur Uracil;

NCIt related terms : Uftoral; Tegafur and uracil;

NCIt definition : A formulated therapeutic oral agent consisting of a combination of the 5-fluorouracil (5-FU) congener prodrug tegafur (tetrahydrofuranyl-5-fluorouracil) and uracil (1:4). The high concentration of uracil reversibly inhibits the uracil-reducing enzyme dihydropyrimidine dehydrogenase (DPD), thereby inhibiting first-pass DPD-mediated hepatic metabolism of the uracil analogue 5-FU and permitting administration of 5-FU as the orally bioavailable prodrug tegafur. Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5-FU, a substance that kills tumor cells. The uracil causes higher amounts of 5-FU to stay inside the cells and kill them. Tegafur-uracil is a type of antimetabolite.;

UNII : HMI5GR78FR;

CAS number : 74578-38-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 74578-38-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Uftoral; Ufur; Tefudex;

NSC code : 719164;

Codes from synonyms : CDR0000530325; CDR0000549434; CDR0000549431; 482;

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16/05/2024


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