Preferred Label : Iodine I 131 Monoclonal Antibody F16SIP;
NCIt synonyms : (131I) Monoclonal Antibody F16SIP; 131I-F16SIP; F16-131I;
NCIt definition : A fully human monoclonal antibody (MoAb) against human A1 domain of tenascin-C, in
small immunoprotein (SIP) format conjugated with iodine 131 with potential antineoplastic
activity. Iodine I 131 MoAb F16SIP binds to tenascin-C on the vascular tissues and
delivers cytotoxic radiation to the tumors, thereby minimizing systemic radiotoxicity.
Tenascin-C is a glycoprotein of the extracellular matrix, and the large isoform of
this matrix protein is expressed and restricted around vascular structures in the
tumor stroma of a variety of different tumors.;
Drug name : Tenarad;
Origin ID : C95025;
UMLS CUI : C2986855;
Semantic type(s)
- concept_is_in_subset
