Chlorotoxin - CISMeF

Preferred Label : Chlorotoxin;

NCIt related terms : CTX;

NCIt definition : A neurotoxin with potential anticancer property. Chlorotoxin (CTX) is a 36-amino acid peptide found in the venom of the deathstalker scorpion, and a chloride channel blocker. This toxin binds preferentially to glioma cells via the transmembrane endopeptidase matrix metalloproteinase-2 (MMP-2), and thereby prevents the spread of tumor cells. MMP-2 is specifically up-regulated in gliomas and related cancers, but is not normally expressed in brain.;

Alternative definition : NCI-GLOSS: A substance being studied in the diagnosis and treatment of glioma (a type of brain cancer) and other types of cancer. It binds to cancer cells in the brain and peripheral nervous system and may keep them from spreading. Chlorotoxin comes from the venom of a type of scorpion. A form of chlorotoxin made in the laboratory is called TM-601. Chlorotoxin is a type of neurotoxin.;

UNII : 06UV5RFW57;

CAS number : 163515-35-3;

Molecule name : TM-601;

Codes from synonyms : CDR0000653110; CDR0000653109;

Details

Origin ID

C94723;

UMLS CUI

C0293227;

Automatic exact mappings (from CISMeF team)
- Cerebrotendinous xanthomatosis [OMIM Phenotype]
- Cerebrotendinous xanthomatosis [ORDO Disease]
- Cyclophosphamide (substance) [SNOMED CT concept]
- TM 601 [MeSH concept]
- cytochrome P450 family 27 subfamily A member 1 [ORDO Gene]
Currated CISMeF NLP mapping
- Chlorotoxin [MeSH concept]
- Chlorotoxin [MeSH Supplementary Concept]
- Chlorotoxin (substance) [SNOMED CT concept]
False automatic mappings
- Cerebrotendinous xanthomatosis [ICD-11 More detail]
- Cyclophosphamide [LOINC component]
- Product containing cyclophosphamide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hazardous or Poisonous Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Chlorotoxin [MeSH Supplementary Concept]
- Chlorotoxin [MeSH concept]
- Chlorotoxin (substance) [SNOMED CT concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients