Preferred Label : Vitamin K;
NCIt related terms : 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione;
NCIt definition : The term vitamin K refers to a group of chemically similar fat-soluble compounds called
naphthoquinones: vitamin K1 (phytonadione) is found in plants and is the primary source
of vitamin K for humans through dietary consumption, vitamin K2 compounds (menaquinones)
are made by bacteria in the human gut, and vitamin K3 (menadione) is a water-soluble
preparation available for adults only. Vitamin K is necessary for the liver to produce
the coagulation factors II, VII, IX, and X, as well as the clotting factors protein
C, protein S, and protein Z; vitamin K deficiency can result in deficiencies of these
coagulation factors and excess bleeding. An injection of vitamin K is routinely given
to newborn infants to prevent vitamin K deficiency bleeding, also known as hemorrhagic
disease of the newborn. Vitamin K deficiency is rare in adults but may result from
chronic malnutrition or an inability to absorb dietary vitamins.;
Alternative definition : CRCH: Fat soluble vitamin that is a coenzyme during the synthesis of the biologically
active form of a number of proteins involved in blood coagulation and bone metabolism.
Vitamin K's structure typically consists of a methylated naphthoquinone ring from
which one or more unsaturated aliphatic side chains are attached at the 3-position
of the ring.; NCI-GLOSS: A nutrient that the body needs in small amounts to function and stay healthy.
Vitamin K helps to form blood clots (a mass that forms when blood platelets, proteins,
and cells stick together) and maintain strong bones. It is fat-soluble (can dissolve
in fats and oils) and is found in green leafy vegetables, broccoli, liver, and vegetable
oils. Vitamin K is also made by bacteria that live in the large intestine. Not enough
vitamin K can lead to bleeding and bruising.;
CAS number : 12001-79-5;
Unit used : mcg;
Chemical formula : C31H46O2;
ChEBI ID : CHEBI:28384;
Codes from synonyms : CDR0000046044;
Origin ID : C943;
UMLS CUI : C0042878;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
