Preferred Label : HLA-A*2402-Restricted CDCA1-A24-56 Peptide Vaccine;
NCIt synonyms : HLA-A*2402-Restricted Cell Division Cycle Associated 1-A24-56 Peptide Vaccine;
NCIt definition : A cancer vaccine containing the HLA-A*2402-restricted peptide epitope derived from
cell division associated gene 1 (CDCA1), with potential immunostimulatory and antitumor
activities. Upon administration, HLA-A*2402-restricted CDCA1-A24-56 peptide vaccine
may stimulate a cytotoxic T lymphocyte (CTL) response against CDCA1-expressing tumor
cells, resulting in tumor cell lysis and decreased tumor cell proliferation. HLA-A*2402
is an MHC class I molecule that presents antigenic peptides to CD8 T cells; epitope
design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve
antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL426035;
Origin ID : C94223;
UMLS CUI : C2986408;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
