NCIt definition : A glycoengineered form of a human monoclonal antibody directed against the epidermal
growth factor receptor (EGFR) with potential antineoplastic activity. Anti-EGFR monoclonal
antibody GT-MAB 5.2-GEX specifically binds to the extracellular domain of EGFR, thereby
potentially inducing an antibody-dependent cell-mediated cytotoxicity (ADCC) against
EGFR-expressing tumor cells, eventually leading to tumor cell apoptosis and an inhibition
of tumor cell growth. EGFR, a member of the epidermal growth factor family of extracellular
protein ligands, is overexpressed on the cell surfaces of various solid tumors. This
antibody has a specific glycosylation profile that may enhance its ADCC response against
EGFR-expressing tumor cells.;