Preferred Label : Indoleamine 2,3-dioxygenase Peptide Vaccine;
NCIt synonyms : IDO Peptide Vaccine;
NCIt definition : A peptide vaccine against the immunomodulatory enzyme indoleamine 2,3-dioxygenase
(IDO), with potential immunomodulating and antineoplastic activities. Vaccination
with indoleamine 2,3-dioxygenase peptide vaccine may activate the immune system to
induce an immune response against IDO-expressing cells. This may increase and restore
the proliferation and activation of various immune cells, including dendritic cells
(DCs), natural killer (NK) cells, and T-lymphocytes, and may eradicate IDO-expressing
tumor cells. IDO, a cytosolic enzyme responsible for tryptophan catabolism and conversion
of tryptophan into kynurenine, is overexpressed by a variety of tumor cell types and
antigen presenting cells (APCs) and plays an important role in immunosuppression;
Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and suppresses
the immune system.;
NCI Metathesaurus CUI : CL426028;
Origin ID : C94215;
UMLS CUI : C2986400;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
