NCIt definition : A synthetic oligonucleotide based on a proprietary double stem-loop immunomodulator
design with potential immunostimulating activity. Lefitolimod binds to and activates
intracellular Toll-like receptor 9 (TLR9) in monocytes/macrophages, plasmacytoidal
and myeloid dendritic cells (DCs), and natural killer (NK) cells, initiating immune
signaling pathways and inducing T-helper 1 cell (Th1) production leading to the production
of memory T cells and a Th1-mediated immune response. By activating the immune system,
MGN1703 may attack tumor associated antigen (TAAs). TLR9 is a member of the TLR family,
which plays a fundamental role in pathogen recognition and activation of innate immunity.;
Automatic exact mappings (from CISMeF team)