Preferred Label : Ad5-SGE-REIC/Dkk-3 MTG-201;
NCIt synonyms : Ad5-SGE-REIC/Dkk3;
NCIt definition : A replication incompetent adenoviral vector type 5 (Ad5) encoding the tumor suppressor
gene dickkopf-3 (DKK3; reduced expression in immortalized cells; REIC; Dickkopf WNT
signaling pathway inhibitor 3), and containing the super gene expression (SGE) system,
composed of the triple tandem enhancer sequences of human telomerase reverse transcriptase
(hTERT), simian virus 40 (SV40) and cytomegalovirus (CMV), with potential immunostimulating
and antineoplastic activities. Upon intratumoral (IT) injection and transfection of
Ad5-SGE-REIC/Dkk-3 MTG-201, tumor cells express REIC/DKK3 protein. This may result
in the activation of c-Jun-NH2-kinase (JNK) and ultimately lead to apoptosis via B-cell
lymphoma-2 (Bcl2) suppression and caspase-3 activation. Increased expression of REIC/DKK3
in cancer cells may lead to an induction of tumor cell apoptosis and a reduction in
tumor cell growth, while sparing normal, healthy cells expressing endogenous REIC/DKK3.
In addition, the tumor cell killing promotes a cytotoxic T-lymphocyte (CTL)-mediated
immune response, thereby further killing any remaining REIC-deficient, untransfected
tumor cells. The SGE system, also called C-TSC (CMV promoter driving the triple tandem
enhancer sequences of hTERT, SV40 and CMV), enhances gene expression compared to more
conventional adenoviral vectors. REIC/DKK3 is expressed by healthy cells, but expression
is reduced or absent in many cancer cells due to REIC/DKK3 gene defects. As REIC/DKK3
plays a key role in tumor cell apoptosis, the absence of the REIC protein in tumor
cells prevents tumor cell apoptosis.;
Molecule name : MTG 201; MTG-201;
Origin ID : C94205;
UMLS CUI : C5239399;
Semantic type(s)
- concept_is_in_subset
- has_target
