Preferred Label : Anti-TAG-72 Monoclonal Antibody CC49-Streptavidin Conjugate;
NCIt related terms : CC49-streptavidin;
NCIt definition : An immunoconjugate containing CC49, a monoclonal antibody (MAb) directed against the
tumor-associated antigen (TAA) tumor-associated glycoprotein 72 (TAG-72), conjugated
to streptavidin, a nonglycosylated homotetrameric protein that has four high affinity
binding sites for biotin, with potential use in pre-targeted radioimmunotherapy (PRIT).
Upon administration of anti-TAG-72 MAb CC49-streptavidin conjugate, the MAb moiety
targets and binds to TAG-72 expressed on cancer cells. Upon subsequent administration
of a biotin-based radioconjugate, such as yttrium Y 90 DOTA-biotin, the biotin moiety
of the radioconjugate binds to the streptavidin moiety of MAb CC49-streptavidin conjugate,
which localizes the biotin-conjugated radionuclide to the tumor site. Upon cellular
internalization, a cytotoxic does of radiation may be specifically delivered to TAG-72-expressing
tumor cells. TAG-72, a human pancarcinoma antigen, is overexpressed on a variety of
cancer cell types.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It is made
by combining the monoclonal antibody CC49 with a chemical called streptavidin. It
can find tumor cells that have the protein TAG-72 on their surface, including colon,
prostate, breast, and ovary cancer cells. After CC49-streptavidin binds to cancer
cells, a radioactive compound called yttrium Y 90 DOTA-biotin will find those cells
and kill them.;
Codes from synonyms : CDR0000393537;
Origin ID : C93264;
UMLS CUI : C2985523;
Semantic type(s)
- concept_is_in_subset
