Preferred Label : Anti-VEGFR Monoclonal Antibody;
NCIt definition : Any monoclonal antibody directed against the human tyrosine kinase vascular endothelial
growth factor receptor (VEGFR), with potential anti-angiogenic and antineoplastic
activities. An anti-VEGFR monoclonal antibody binds to and inhibits the activity of
VEGFR, which may prevent the activation of downstream signaling pathways and tumor
angiogenesis; the subsequent reduction in tumor nutrient supply may inhibit tumor
cell proliferation. The expression of the pro-angiogenic growth factor VEGF is associated
with tumor angiogenesis and tumor cell proliferation and invasion.;
Alternative definition : NCI-GLOSS: A monoclonal antibody being studied in the treatment of some types of cancer.
Monoclonal antibodies are made in the laboratory and can locate and bind to substances
in the body, including cancer cells. Anti-VEGFR monoclonal antibodies bind to receptors
for vascular endothelial growth factor (VEGF) and keeps VEGF from binding to them.
This may stop the growth of new blood vessels that tumors need to grow. It is a type
of antiangiogenesis agent.;
Codes from synonyms : CDR0000600434;
Origin ID : C93170;
UMLS CUI : C2985475;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
