KMT2C wt Allele

Preferred Label : KMT2C wt Allele;

NCIt synonyms : Myeloid/Lymphoid or Mixed-Lineage Leukemia 3 Gene; FLJ38309; DKFZp686C08112; HALR; FLJ12625; MGC119853; MLL3 wt Allele; KIAA1506; MGC119851; Lysine Specific Methyltransferase 2C wt Allele; Lysine (K)-Specific Methyltransferase 2C Gene; KLEFS2;

NCIt definition : Human KMT2C wild-type allele is located in the vicinity of 7q36.1 and is approximately 302 kb in length. This allele, which encodes histone-lysine N-methyltransferase 2C protein, is involved in the modulation of both transcription and histone methylation.;

NCIt note : The MLL3 gene is found in a critical region of chromosome 7, which is commonly deleted in malignant myeloid disorders. Partial duplications of the MLL3 gene are found in the juxtacentromeric region of chromosomes 1, 2, 13 and 21. This reshuffling of the MLL3 gene has generated the BAGE genes.;

GenBank Accession Number : AF264750;

Details

Origin ID

C93092;

UMLS CUI

C2985429;

OMIM relation
- Lysine-specific methyltransferase 2c [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 7q36.1 [NCIt concept]
gene_plays_role_in_process
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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