Acute Myeloid Leukemia with Multilineage Dysplasia

Preferred Label : Acute Myeloid Leukemia with Multilineage Dysplasia;

NCIt synonyms : AML with Multilineage Dysplasia; De Novo Acute Myeloid Leukemia with Multilineage Dysplasia; AML-MLD;

NCIt definition : An acute myeloid leukemia arising de novo and not as a result of treatment. It is characterized by the presence of myelodysplastic features in at least 50% of the cells of at least two hematopoietic cell lines. Patients often present with severe cytopenia.;

Neoplastic status : Malignant;

ICD-O code : 9895/3;

Details

Origin ID

C9289;

UMLS CUI

C1292773;

Currated CISMeF NLP mapping
- Acute myeloid leukaemia with myelodysplasia-related changes [ICD-11 Extension code]
- Acute myeloid leukaemia with myelodysplasia-related features [ORDO Disease]
- Acute myeloid leukemia myelodysplasia related (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia with multilineage dysplasia [ICD-O code]
- Acute myeloid leukemia with myelodysplasia-related changes (disorder) [SNOMED CT concept]
Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Granulocytopenia [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Pancytopenia [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Thrombocytosis [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Manual BTNT mappings - CISMeF
- acute myeloid leukemia with trilineage dysplasia [Disease (Nov.)]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Acute myeloid leukaemia with myelodysplasia-related features [ORDO Disease]
Validated automatic mappings to NTBT
- acute myeloid leukemia and myelodysplasia [Disease (Nov.)]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
- Secondary Lesion [NCIt concept]
- Solid Growth Pattern [NCIt concept]
- Therapy-Related Toxicity [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
- TP53 Gene Mutation [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 20 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Bone Marrow Dysplasia Present in 50 Percent or More of the Cells of Two Cell Lines [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Multilineage Dysplasia Present [NCIt concept]
- Myeloblasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 11 [NCIt concept]
- Gain of Chromosome 19 [NCIt concept]
- Gain of Chromosome 21 [NCIt concept]
- Gain of Chromosome 8 [NCIt concept]
- Gain of Chromosome 9 [NCIt concept]
- Loss of Chromosome 11q ATM Gene Locus [NCIt concept]
- Loss of Chromosome 12p [NCIt concept]
- Loss of Chromosome 5q [NCIt concept]
- del(20)(q11) [NCIt concept]
- del(7)(q11;q36) [NCIt concept]
- ins(3;3) [NCIt concept]
- inv(3)(q21.3;q26.2) [NCIt concept]
- t(3;3)(q21.3;q26.2) [NCIt concept]
- t(3;5)(q25;q34) [NCIt concept]

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