MALAT1 wt Allele

Preferred Label : MALAT1 wt Allele;

NCIt synonyms : NEAT2; Nuclear Enriched Abundant Transcript 2 Gene; Metastasis Associated Lung Adenocarcinoma Transcript 1 (Non-Protein Coding) wt Allele; Alpha Gene; MALAT-1; Metastasis Associated In Lung Adenocarcinoma Transcript 1 Gene; Hepcarcin Gene; Non-Protein Coding RNA 47 Gene; PRO1073; Nuclear Paraspeckle Assembly Transcript 2 (Non-Protein Coding) Gene; HCN; PRO2853; NCRNA00047;

NCIt definition : Human MALAT1 wild-type allele is located in the vicinity of 11q13.1 and is approximately 9 kb in length. This allele, which encodes metastasis-associated lung adenocarcinoma transcript 1 non-coding RNA, may be involved in tumorigenesis. Aberrant expression of the gene is associated with non-small cell lung cancer and the gene may be involved in a translocation t(6;11)(p21.1;q13) with the human TFEB gene that may be associated with renal cell carcinoma.;

NCIt note : The 3-prime end of MALAT1 can be cleaved to form a tRNA like molecule called mascRNA. (Cell 2008; 135:919-32.);

GenBank Accession Number : AF001540;

Details

Origin ID

C92697;

UMLS CUI

C2985256;

OMIM relation
- Metastasis-associated lung adenocarcinoma transcript 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_in_chromosomal_location
- 11q13.1 [NCIt concept]
gene_plays_role_in_process
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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