MTHFD1L wt Allele

Preferred Label : MTHFD1L wt Allele;

NCIt synonyms : DKFZp586G1517; Monofunctional C1-Tetrahydrofolate Synthase, Mitochondrial Gene; Mitochondrial C1-Tetrahydrofolate Synthase Gene; MTC1THFS; 10-Formyl-Thf Synthetase Gene; RP1-292B18.2; FLJ21145; Methylenetetrahydrofolate Dehydrogenase (NADP Dependent) 1-Like wt Allele; dJ292B18.2; Formyltetrahydrofolate Synthetase Domain Containing 1 Gene; FTHFSDC1;

NCIt definition : Human MTHFD1L wild-type allele is located in the vicinity of 6q25.1 and is approximately 236 kb in length. This allele, which encodes monofunctional C1-tetrahydrofolate synthase, mitochondrial protein, plays a role in the modulation of mitochondrial folate metabolism. Genetic variation may be associated with Alzheimer disease.;

NCIt note : The MTHFD1L gene and gene product may participate in the progression of colorectal cancer by conferring growth advantage; and therefore could be a new molecular target for cancer therapy. (UniProt);

GenBank Accession Number : BC017477;

Details

Origin ID

C92694;

UMLS CUI

C2985254;

OMIM relation
- Methylenetetrahydrofolate dehydrogenase 1-like, nadp(+)-dependent [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 6q25.1 [NCIt concept]
gene_is_element_in_pathway
- Glyoxylate and Dicarboxylate Metabolism Pathway [NCIt concept]
- One Carbon Pool by Folate Pathway [NCIt concept]
gene_plays_role_in_process
- Folic Acid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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