Preferred Label : DNA Interference Oligonucleotide PNT2258;
NCIt definition : A liposomal formulation of the 24-mer oligonucleotide PNT100, with potential antineoplastic
activity. PNT2258 targets and complements to untranscribed DNA sequence upstream of
BCL2 promoters, thereby interfering with DNA replication and transcription of the
BCL2 gene. This may promote and restore the apoptotic pathway in BCL2-overexpressing
tumor cells. BCL2, an anti-apoptotic protein, is overexpressed in a wide variety of
tumors.;
Drug name : DNAi Drug PNT2258;
Molecule name : PNT2258;
Origin ID : C92588;
UMLS CUI : C2985197;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
