Preferred Label : Recombinant PRAME Protein Plus AS15 Adjuvant GSK2302025A;
NCIt definition : A recombinant form of the human PRAME (Preferentially Expressed Antigen of Melanoma)
protein combined with the AS15 adjuvant, with potential immunostimulatory and antineoplastic
activities. Upon intramuscular administration, GSK2302025A may stimulate the host
immune response to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells
that overexpress the PRAME protein, resulting in tumor cell lysis. The tumor-associated
antigen PRAME is often overexpressed by a variety of tumor cell types. AS15 is an
potent adjuvant liposomal formulation that contains CpG 7909, monophosphoryl lipid,
and QS-21.;
NCI Metathesaurus CUI : CL421638;
Origin ID : C92586;
UMLS CUI : C2985195;
Semantic type(s)
- concept_is_in_subset
