Preferred Label : E. coli CD-expressing Genetically Modified Neural Stem Cells;
NCIt definition : Genetically-modified neural stem cells (NSCs) transfected with the Escherichia coli
(E. coli) suicidal gene cytosine deaminase (CD), with potential antineoplastic adjuvant
activity. Upon intracerebral injection, E. coli CD-expressing genetically modified
NSCs express the E. coli cytosine deaminase, an enzyme that catalyzes the intracellular
conversion of the nontoxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil
(5-FU). Co-administration of this agent with 5-FC and upon local activation of 5-FU
in the brain tumor, 5-FU disrupts DNA synthesis in tumor cells thereby impeding cellular
proliferation with minimal systemic exposure and toxicity.;
NCI Metathesaurus CUI : CL421632;
Origin ID : C92585;
UMLS CUI : C2985194;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
