Preferred Label : Polyethylene Glycol Recombinant Endostatin;
NCIt related terms : ENDOSTAR, MONOPEG-20000;
NCIt definition : A formulation containing recombinant endostatin attached to polyethylene glycol (PEG),
with potential anti-angiogenic and antineoplastic activities. Endostatin, a 20 kDa
C-terminal proteolytic fragment of collagen XVIII, induces microvascular endothelial
cell apoptosis and inhibits endothelial proliferation and angiogenesis, which may
result in a reduction of tumor cell growth. Modification with PEG extends the circulation
half-life of endostatin, improves stability and increases solubility in organic solvents.;
UNII : SLQ3VZ4GSC;
Molecule name : M2ES;
NCI Metathesaurus CUI : CL419349;
Origin ID : C92583;
UMLS CUI : C2985192;
Semantic type(s)
- concept_is_in_subset
