Preferred Label : PSA-PAP/KLH-pulsed Autologous Dendritic Cell Vaccine;
NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with
the prostate-specific tumor associated antigens (TAAs) prostate specific antigen (PSA)
and prostate acid phosphatase (PAP), and conjugated to the immunostimulant Keyhole
limpet hemocyanin (KLH), with potential immunostimulatory and antineoplastic activities.
Upon administration, prostate cancer antigen/KLH-pulsed autologous dendritic cell
vaccine may stimulate the immune system to mount anti-tumoral cytotoxic T lymphocyte
(CTL) and antibody responses against prostate cancer cells expressing PSA and PAP,
which may result in prostate cancer cell lysis. KLH is an immunogenic carrier and
serves as an immunostimulant to improve antigenic immune recognition and T-cell responses
and can be used to evaluate vaccine efficacy.;
Drug name : CreaVax-PC;
NCI Metathesaurus CUI : CL421674;
Origin ID : C92573;
UMLS CUI : C2985181;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
