Preferred Label : Phaleria macrocarpa Extract DLBS-1425;
NCIt definition : An extract of the flesh from the fruit of Phaleria macrocarpa, an Indonesian herbal
medicine, with potential antineoplastic activity. Although the active ingredients
and exact components are unclear, gallic acid and its derivatives in DLBS-1425 appear
to inhibit the phosphoinositide-3 kinase (PI3K)/protein kinase B (AKT) signaling pathway
by reducing PI3K transcription followed by a reduction in AKT phosphorylation. This
extract also appears to induce apoptosis through induction of pro-apoptotic genes
such as BAX, BAD and PUMA and inhibition of the apoptosis suppressor Bcl-2.;
Molecule name : DLBS-1425;
Origin ID : C91739;
UMLS CUI : C2984527;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
