Preferred Label : NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes;
NCIt definition : Exosomes loaded with non-small cell lung cancer (NSCLC)-specific antigens, with potential
immunostimulating and antineoplastic activities. Exosomes derived from autologous
maturing dendritic cells (DCs) are pulsed with HLA-DP04-restricted MAGE-3, and HLA-A02-restricted
peptides NY-ESO-1, MAGE-1, MAGE-3, and MART-1. Upon vaccination, these exosomes may
stimulate natural killer (NK) cell activation and proliferation, restoration of NKG2D
expression on NK cells, and antigen-specific T-cell responses. This may eventually
lead to inhibition of tumor cell proliferation in NSCLC expressing these specific
tumor antigens. These exosomes, nanovesicles secreted from DCs, are embedded with
molecules necessary for potent immune responses on the exosomal surface, such as MHC
class II molecules, CD40, ICAM-1, IL-15Ralpha, and NKG2D ligands.;
Origin ID : C91738;
UMLS CUI : C2984526;
Semantic type(s)
- concept_is_in_subset
