NCIt synonyms : DNA (Synthetic Toca 511-encoding Retroviral Vector AC3-yCD2(V));
NCIt definition : A replication competent retroviral vector, derived from the Moloney murine leukemia
virus (MoMLV), encoding a modified form of the yeast suicide gene cytosine deaminase
(CD) (Toca 511) used as an antineoplastic adjuvant. Upon transcranial injection, vocimagene
amiretrorepvec preferentially enters and transfects tumor cells, and expresses cytosine
deaminase, an enzyme that catalyzes the intracellular conversion of the prodrug flucytosine
(5-FC) into the antineoplastic agent 5-fluorouracil (5-FU). After administration of
5-FC, the tumor can be eradicated upon activation of 5-FU.;
Currated CISMeF NLP mapping