Preferred Label : Urokinase-Derived Peptide A6;
NCIt synonyms : uPA-derived Peptide A6;
NCIt related terms : A6; urokinase plasminogen activator (uPA)-derived peptide A6; ACETYL-LYS-PRO-SER-SER-PRO-PRO-GLU-GLU-NH2;
NCIt definition : An octapeptide (amino acids 136-143) derived from the proteolytic enzyme urokinase
plasminogen activator (uPA), with potential antineoplastic activity. A6 is derived
from the nonreceptor-binding domain and connecting region of urokinase. Administration
of A6 inhibits the interaction of uPA with its receptor uPAR, and may inhibit endothelial
cell motility and tumor cell invasion. uPA and uPAR promote extracellular matrix degradation
and growth factor activation and correlate positively with angiogenesis, cancer cell
invasion and metastasis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. A6 is a small piece
of a protein called urokinase (an enzyme that dissolves blood clots or prevents them
from forming). It is a type of antiangiogenesis agent and a type of antimetastatic
agent.;
UNII : KM64V5W7RA;
CAS number : 220334-14-5;
Molecule name : A6;
NCI Metathesaurus CUI : CL433998;
Codes from synonyms : CDR0000658764; CDR0000658765;
Origin ID : C91709;
UMLS CUI : C2984503;
Semantic type(s)
- concept_is_in_subset
- has_target
