Preferred Label : Quaratusugene Ozeplasmid;
NCIt definition : A formulation composed of DOTAP:cholesterol liposomal nanoparticles complexed with
a plasmid expression cassette encoding human FUS1 protein, with potential antineoplastic
activity. Upon administration, DOTAP:chol-Fus1 liposome complex accumulates mainly
in the lungs and particularly in cancer cells. Upon transfer of the Fus1 gene into
tumor cells, the expression of Fus1 may induce tumor cell apoptosis and suppress tumor
cell proliferation. Fus1, a potent tumor-suppressor protein, is present in normal,
healthy cells but often absent in certain cancer cells. DOTAP:cholesterol liposome
is composed of cationic lipid dioleoyl-trimethylammonium propane (DOTAP) and cholesterol
at a molar ratio of 1:1.;
UNII : LD93JWY9D9;
CAS number : 1396823-56-5;
Drug name : Reqorsa;
Molecule name : INGN 401; GPX 001; GPX-001;
Origin ID : C91708;
UMLS CUI : C5557438;
Semantic type(s)
- concept_is_in_subset
