Preferred Label : Autologous GM-CSF-secreting Lethally Irradiated Pancreatic Cancer Vaccine;
NCIt synonyms : Autologous GVAX Pancreatic Cancer Vaccine;
NCIt definition : An irradiated, autologous pancreatic cancer vaccine consisting of patient-specific
pancreatic cancer cells genetically modified to secrete the cytokine granulocyte-macrophage
colony stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic
activities. Upon vaccination, GVAX pancreatic cancer vaccine secretes GM-CSF. In turn,
GM-CSF may stimulate the body's immune system against tumor cells by enhancing the
activation of dendritic cells (DCs) and promoting antigen presentation to both B-
and T-cells. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity
(ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.;
NCI Metathesaurus CUI : CL554538;
Origin ID : C91707;
UMLS CUI : C4727600;
Semantic type(s)
- concept_is_in_subset
