Preferred Label : Chinese Herbal Formulation PHY906;
NCIt synonyms : TCM PHY906;
NCIt definition : An oral traditional Chinese herbal formulation in powder form containing a spray-dried
preparation of an aqueous extract from the four herbs Scutellaria baicalensis, Glycyrrhiza
uralensis, Ziziphus jujuba and Paeonia lactiflora, with potential immunomodulating
and chemoprotective activities, and which may be used as an adjuvant for chemotherapeutic
agents. Although the mechanisms of action remain to be fully elucidated, PHY906 possesses
a wide range of pharmacological activities such as the enhancement of oral uptake
of pharmacologically active agents, inhibition of CYP3A4, modulation of certain pro-inflammatory
cytokines, enhanced migration of macrophages and lymphocytes, and the inhibition of
expression of matrix metalloproteinase (MMP), nuclear factor kappaB (NF-kB), cyclooxygenase
(COX), nitric oxide synthase (NOS), beta-glucuronidase, the neurokinin 1 receptor
(NK1R; tachykinin receptor 1; TACR1; substance-P receptor) and the delta-opioid receptor.
PHY906 may also enhance the anti-tumor effect of other anti-cancer agents, and may
protect the gastrointestinal (GI) mucosa against damage and reduce GI symptoms.;
Molecule name : PHY906; YIV-906; KD-018; YIV 906;
Origin ID : C91704;
UMLS CUI : C1260030;
Semantic type(s)
- UMLS correspondences (same concept)
- PHY 906 [MeSH Supplementary Concept]
- concept_is_in_subset
