Preferred Label : Galactomannan Derivative;
NCIt related terms : DAVANAT;
NCIt definition : A carbohydrate polymer composed of mannose and galactose, with chemotherapeutic enhancing
activity. Galactomannan derivative binds to galectins on cell surfaces and may promote
the transport of certain chemotherapeutics, such as 5-fluorouracil (5-FU), into tumor
cells. This may increase the antineoplastic effect of 5-FU when administered concomitantly.
Galectins are carbohydrate-binding proteins, upregulated on the surface of certain
types of tumor cells, and may mediate cell association, survival and metastasis.;
UNII : C2BXC3OWPA;
CAS number : 916851-14-4;
Origin ID : C91703;
UMLS CUI : C1328725;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
