NCIt related terms : pegylated arginine deiminase; ADI-PEG 20;
NCIt definition : An agent consisting of the arginine-degrading enzyme arginine deiminase combined with
polyethylene glycol (20,000 MW) (ADI-PEG 20) with potential antineoplastic activity.
Upon administration, pegargiminase breaks down the amino acid arginine into citrulline.
Although arginine is a nonessential amino acid for normal human cells, certain cancer
cells are autotrophic for arginine and need arginine in order to survive. Depletion
of arginine may lead to an inhibition of cellular proliferation in those cancer cells.
ADI is coupled to PEG in order to enhance this agent's half-life.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of melanoma, liver cancer, and
other types of cancer. It breaks down the amino acid arginine and may block the growth
of cancer cells that need arginine to grow. It is a type of iminohydrolase.;
UNII : 0B7PYQ9YRT;
CAS number : 1394129-74-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1394129-74-8
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G-SRS /a ;
Codes from synonyms : CDR0000543120; CDR0000562556;
Currated CISMeF NLP mapping