Collecting Duct Acid Secretion Pathway

Preferred Label : Collecting Duct Acid Secretion Pathway;

NCIt related terms : Collecting duct acid secretion;

Alternative definition : KEGG: One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H( )-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate.;

KEGG ID : hsa04966;

Details

Origin ID

C91493;

UMLS CUI

C2984304;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Band 3 Anion Transport Protein [NCIt concept]
- Carbonic Anhydrase 2 [NCIt concept]
- Solute Carrier Family 12 Member 7 [NCIt concept]
- V-Type Proton ATPase 116 kDa Subunit A 1 [NCIt concept]
- V-Type Proton ATPase 116 kDa Subunit A 3 [NCIt concept]
- V-Type Proton ATPase Subunit B, Brain Isoform [NCIt concept]
pathway_has_gene_element
- ATP6V0A1 wt Allele [NCIt concept]
- ATP6V1B2 wt Allele [NCIt concept]
- CA2 wt Allele [NCIt concept]
- SLC12A7 wt Allele [NCIt concept]
- SLC4A1 wt Allele [NCIt concept]
- TCIRG1 wt Allele [NCIt concept]

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