Preferred Label : F16-IL2 Fusion Protein;
NCIt synonyms : Teleukin;
NCIt definition : An immunocytokine of the human monoclonal antibody fragment F16 (scFv) against the
extra-domain A1 of tenascin-C fused, via a short 5-amino acid linker, to a recombinant
form of the human cytokine interleukin-2 (IL-2) with potential immunostimulating and
antineoplastic activities. The monoclonal antibody portion of the F16-IL2 fusion protein
binds to tumor cells expressing the tumor associated antigen (TAA) tenascin-C. In
turn, the IL-2 moiety of the fusion protein stimulates natural killer (NK) cells,
macrophages and neutrophils and induces T-cell antitumor cellular immune responses
thereby selectively killing tenascin-C-expressing tumor cells. In addition, F16-IL2
may potentiate the cytotoxicity of other chemotherapeutic agents. Tenascin-C, a glycoprotein
of the extracellular matrix, is expressed in many cancer cell types.;
NCI Metathesaurus CUI : CL421592;
Origin ID : C91395;
UMLS CUI : C2984216;
Semantic type(s)
- concept_is_in_subset
