Preferred Label : Deuterated 3-Methylhistidine;
NCIt definition : A derivative of the amino acid histidine labeled with heavy hydrogen (D) used in diagnostic
procedures. Upon intake of deuterated 3-methylhistidine (3-MH), this agent is incorporated
into muscle protein and then is subsequently excreted unchanged in the urine. By measuring
the amount of 3-MH in the urine, via analysis of deuterium, the rate of protein muscle
catabolism can be determined and the risk of skeletal muscle atrophy or cachexia can
be assessed. 3-methylhistidine is a myofibrillar-specific amino acid and is mainly
found in muscle myosin and actin; proteolysis of myofibrils releases 3-MH that is
excreted unchanged in the urine.;
NCI Metathesaurus CUI : CL421639;
Origin ID : C91391;
UMLS CUI : C2984212;
Semantic type(s)
- concept_is_in_subset
