Preferred Label : Iodine I 131 Anti-Fibronectin Antibody Fragment L19-SIP;
NCIt synonyms : L19-SIP;
NCIt definition : An iodine 131 radioimmunoconjugate of a small immunoprotein (SIP), derived from the
variable region fragment of human monoclonal antibody L19, that is directed against
the extra-domain B (ED-B) of fibronectin, with potential radioimmunotherapeutic activity.
The SIP moiety of iodine I 131 anti-fibronectin antibody fragment L19-SIP binds to
the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. Upon internalization,
the I 131 radionuclide may selectively detect or deliver cytotoxic radiation to fibronectin-expressing
tumor cells. ED-B of fibronectin, a naturally occurring marker of tissue remodeling
and angiogenesis, is expressed in the majority of aggressive solid human tumors, whereas
it is not detectable in normal vessels and tissues.;
NCI Metathesaurus CUI : CL421588;
Origin ID : C91389;
UMLS CUI : C2984210;
Semantic type(s)
- concept_is_in_subset
