Preferred Label : Anti-PGF Monoclonal Antibody RO5323441;
Obsolete resource : true;
NCIt definition : A humanized IgG1 monoclonal antibody directed against the placenta growth factor (PGF),
with potential anti-angiogenic and antineoplastic activities. Anti-PGF monoclonal
antibody RO5323441 binds to both PGF-1 and -2, thereby inhibiting the binding of PGF-1
and -2 to the vascular endothelial growth factor receptor-1 (VEGFR-1) and subsequent
VEGFR-1 phosphorylation. This may result in the inhibition of tumor angiogenesis and
tumor cell proliferation. PGF, a member of the VEGF sub-family and a key molecule
in angiogenesis and vasculogenesis, is upregulated in many cancers.;
NCIt note : See 'Anti-PLGF Monoclonal Antibody TB-403(C78486)';
Concept status : Retired_Concept;
Molecule name : RO5323441; THR 317; THR-317;
Origin ID : C91386;
UMLS CUI : C2984207;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
