Preferred Label : Melanoma TRP2 CTL Epitope Vaccine SCIB1;
NCIt definition : A proprietary DNA-based cancer vaccine that encodes a melanoma antigen tyrosinase-related
protein 2 (TRP2) cytotoxic T-lymphocyte (CTL) epitope and a modified monoclonal antibody,
a chimera of human IgG1/murine IgG2a with T cell mimotopes expressed within the complementarity-determining
regions (CDR) of the antibodies, with potential immunostimulating and antineoplastic
activities. Upon intramuscular injection and electroporation, melanoma TRP2 CTL epitope
vaccine SCIB1 expresses the modified antibody. Subsequently, the Fc component of the
engineered antibody targets and binds to the CD64 receptor on the dendritic cells
(DCs); upon processing by DCs, the cellular immune system may be activated to induce
helper T-cell and CTL immune responses against tumor cells expressing the TRP2 antigen.;
Molecule name : SCIB1;
NCI Metathesaurus CUI : CL421601;
Origin ID : C91380;
UMLS CUI : C2984202;
Semantic type(s)
- concept_is_in_subset
