Preferred Label : Adenoviral Vector Ad5-CEA(6D) Vaccine;
NCIt synonyms : Ad5 CEA Vaccine;
NCIt related terms : ETBX-011;
NCIt definition : A replication-defective, E1- and E2b-deleted oncolytic adenoviral serotype 5 (Ad5)
encoding an epitope of human carcinoembryonic antigen (CEA) with potential antineoplastic
activity. Adenoviral vector Ad5-CEA(6D) vaccine expresses a highly immunogenic analogue
of CEA [CAP1-(6D)]. Upon administration, this vaccine may induce both humoral and
cellular immune responses against tumor cells expressing the CEA antigen, thereby
resulting in the immune-mediated inhibition of tumor cell proliferation and tumor
cell death. CEA, a tumor-associated antigen, is overexpressed in various tumor cell
types. Deletion of early genes E1 and E2b in Ad5 potentially circumvent pre-existing
anti-adenovirus immunity and is capable of inducing strong immune responses.;
UNII : RP9RQ0SOM8;
CAS number : 2035095-05-5;
Molecule name : ETBX-011;
NCI Metathesaurus CUI : CL421635;
Origin ID : C91373;
UMLS CUI : C2984195;
Semantic type(s)
- concept_is_in_subset
- has_target
