Preferred Label : Phosphatidylcholine Biosynthesis Pathway;
Alternative definition : BIOCARTA: The main components of biological membranes are phosphoglyceride lipids
composed of a glycerol unit esterified to two fatty acids and a polar alcohol group.
The properties of phospholipids give lipid bilayer membranes their self-organizing
structure. The polar alcohol group is hydrophilic and organizes itself in the membrane
facing outward toward water, while the hydrophobic fatty acid alkyl chains face inward
toward other fatty acid chains. One of the primary membrane phospholipids is phosphatidylcholine,
in which the polar head group is composed of phosphocholine. The biosynthesis of phosphatidylcholine
and phosphatidylethanolamine follow similar routes. The first step in phosphatidylcholine
is the phosphorylation of choline to make phosphocholine, which is then activated
by CTP. CDP-choline reacts with diacylglycerol to produce phosphatidylcholine (This
definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : pcsynthesispathway;
Origin ID : C91316;
UMLS CUI : C2984157;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
