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B Cell Receptor Complex Signaling Pathway - CISMeF
B Cell Receptor Complex Signaling PathwayNCIt concept
Preferred Label : B Cell Receptor Complex Signaling Pathway;
NCIt related terms : B Cell Receptor Complex;
Alternative definition : BIOCARTA: B cells produce immunoglobulins (Ig, antibodies) that specifically bind
antigen molecules. B cells first produce a membrane-bound form of immunoglobulin,
the B cell receptor, as part of B cell differentiation. Each B cell expresses one
immunoglobulin but the population of B cells in each individual display a wide variety
of antigen specificity, with each cell expressing Ig on its surface as part of the
B cell receptor complex. When the B cell receptor binds to antigen, it initiates a
signal through other proteins non-covalently associated with it in the B cell receptor
complex, the Ig-alpha (CD79a) and Ig-beta (CD79b) chains. The signal initiated by
binding of antigen to the B cell receptor complex causes growth and proliferation
of the B cell and the creation of an amplified clone of effector cells that secrete
the antigen-specific immunoglobulin. Activation of the B cell receptor by antigen
also results in the production of memory cells that persist in circulation to produce
a more rapid immune response after future challenges by the same antigen. (This definition
may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Automatic exact mappings (from CISMeF team)