Preferred Label : Small Leucine-Rich Proteoglycan (SLRP) Pathway;
NCIt related terms : Small Leucine-Rich Proteoglycan (SLRP) Molecules;
Alternative definition : BIOCARTA: The small leucine-rich proteoglycans (SLRPs) are a family of proteins that
are present in extracellular matrix and that share in common multiple repeats of a
leucine-rich structural motif, flanked by cysteine residues. These proteins appear
to interact in many cases with collagen, modifying the deposition and arrangement
of collagen fibers in the extracellular matrix, and also with cells and with soluble
growth factors. The interaction of SLRPs with cells and with growth factors like TGF-beta
may affect the proliferation of cells in addition to modifying the extracellular environment.
Post-translational modification of SLRPs with carbohydrates and sulfate-containing
groups appears to modify the function of SLRPs. Changes in SLRP expression and modification
in cornea, atherosclerotic plaque, joints, bone, tendons, and kidney may be associated
with disease progression in those tissues. Decorin is one SLRP expressed throughout
the body that stabilizes collagen fibrils and that also antagonizes the action of
the cytokine TGF-beta, blocking cell cycle progression, and potentially playing a
role in cancer and wound healing. The SLRP biglycan is expressed in bone and other
connective tissues and genetic disruption of biglycan in mice causes low bone mass
similar to osteoporosis. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_slrpPathway;
Origin ID : C91302;
UMLS CUI : C2984143;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
