Preferred Label : Recombinant Attenuated Salmonella typhimurium Expressing IL-2;
NCIt definition : An orally available, genetically engineered Salmonella typhimurium strain expressing
a truncated form of the human cytokine interleukin-2 (IL-2) gene, with antitumor activity.
Upon administration of recombinant attenuated S. typhimurium expressing IL-2 (SalpIL2),
this Salmonella strain may selectively accumulate and divide in a variety of tumor
types, and express IL-2. In turn, IL-2 may induce natural killer (NK) cell proliferation
thereby enhancing their activity. This may inhibit the growth of tumor cells.;
NCI Metathesaurus CUI : CL421482;
Origin ID : C91096;
UMLS CUI : C2984035;
Semantic type(s)
- concept_is_in_subset
