Preferred Label : Docetaxel-PNP;
NCIt synonyms : PNP-DTX;
NCIt definition : A polymeric nanoparticle (PNP) formulation containing the taxane docetaxel, a semi-synthetic
analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically
to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting
microtubule disassembly, which results in cell-cycle arrest at the G2/M phase, preventing
cell proliferation. This agent also inhibits pro-angiogenic factors such as vascular
endothelial growth factor (VEGF) and induces various mediators of the inflammatory
response. Compared to docetaxel alone, the PNP formulation may enhance stability and
improve delivery.;
NCI Metathesaurus CUI : CL421475;
Origin ID : C91087;
UMLS CUI : C2984028;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
