Preferred Label : Uracil Ointment;
NCIt definition : A 0.1% topical formulation of uracil used potentially to lower the incidence of hand-foot
syndrome (HFS) (or palmar-plantar erythrodysesthesia) during 5-fluorouracil (5-FU)
or 5-FU prodrug capecitabine chemotherapy. Upon local administration of uracil ointment
to the skin, uracil competes with capecitabine or 5-FU as substrates for the activating
enzyme thymidine phosphorylase and the metabolizing enzyme dihydropyrimidine dehydrogenase.
This may prevent the production of 5-FU as well as the breakdown of 5-FU into the
toxic metabolites locally. As the 5-FU metabolites are responsible for the presentation
of HFS, inhibiting their formation may prevent this adverse effect. By applying a
high concentration of uracil locally, the skin toxicities of 5-FU may be countered
while preserving the systemic anti-cancer activity of the 5FU.;
NCI Metathesaurus CUI : CL416292;
Origin ID : C91083;
UMLS CUI : C2984023;
Semantic type(s)
- concept_is_in_subset
