Preferred Label : Aurora B/C Kinase Inhibitor GSK1070916A;
NCIt related terms : GSK-1070916;
NCIt definition : An ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential
antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits
the activity of Aurora B and C, which may result in inhibition of cellular division
and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases
B and C. Aurora kinases play essential roles in mitotic checkpoint control during
mitosis, and are overexpressed by a wide variety of cancer cell types.;
UNII : 8VLB51V7HO;
CAS number : 942918-07-2;
Molecule name : GSK1070916A;
NCI Metathesaurus CUI : CL416287;
Origin ID : C91081;
UMLS CUI : C2984022;
Semantic type(s)
- concept_is_in_subset
- has_target
