Aurora B/C Kinase Inhibitor GSK1070916A

Preferred Label : Aurora B/C Kinase Inhibitor GSK1070916A;

NCIt definition : An ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits the activity of Aurora B and C, which may result in inhibition of cellular division and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases B and C. Aurora kinases play essential roles in mitotic checkpoint control during mitosis, and are overexpressed by a wide variety of cancer cell types.;

Molecule name : GSK1070916A;

NCI Metathesaurus CUI : CL416287;

Details

Origin ID

C91081;

UMLS CUI

C2984022;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Aurora Kinase A [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase B [NCIt concept]
- Aurora Kinase C [NCIt concept]

Keyword's position in hierarchy(ies) :

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