NCIt definition : An ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential
antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits
the activity of Aurora B and C, which may result in inhibition of cellular division
and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases
B and C. Aurora kinases play essential roles in mitotic checkpoint control during
mitosis, and are overexpressed by a wide variety of cancer cell types.;
Semantic type(s)